"I am angry and I am frustrated at the behavior of some of our students and others after the game," he said. "The worst of the postgame behavior Saturday night was unacceptable, dangerous and inexcusable. We cannot and will not tolerate it."
The WVU Office of Student Affairs had either suspended or expelled 40 students before this weekend, he said.
University officials plan to review videotapes and any student identified as breaking the law will face civil and school penalties, which could include expulsion, said Ken Gray, WVU vice president of student affairs.
"It's unfortunate that despite the coordinated efforts of the university -- including students, law enforcement and the administration, and city of Morgantown officials, there remain a few individuals who choose to celebrate West Virginia University athletic successes unsafely and inappropriately," Gray said in a prepared statement.
"We will continue to seek ways to stop this kind of behavior, including through education, communication and cooperation," he said.
On Sept. 30, a street fire set following the WVU-Baylor game destroyed three vehicles and damaged a house.
"Whatever good has been done in the past has been all wiped out," Manilla said. "We're getting close to an injury or loss of life.
"I know we need more police officers," he said. "It's pretty obvious at this point."
Manilla planned to meet with police and fire officials and the city manager this week to discuss the incidents.