Father Giuseppe Piemontese - an Assisi-based official of the Franciscan order, founded to further the cause of peace - lamented that there are "so many, too many" tragic shootings that "raise the question about the ease with which you can legally procure arms in the United States, to then use them in a murderous way."
The attack quickly dominated public discussion in China, rocketing to the top of topic lists on social media and becoming the top story on state television's main noon newscast.
China has seen several rampage attacks at schools in recent years, though the attackers there usually use knives and not guns. The most recent attack happened Friday, when a knife-wielding man injured 22 children and one adult outside a primary school in central China.
With more than 100,000 Chinese studying in U.S. schools, a sense of shared grief came through.
"Parents with children studying in the U.S. must be tense. School shootings happen often in the U.S. Can't politicians put away politics and prohibit gun sales?" Zhang Xin, a wealthy property developer, wrote on her feed on the Twitter-like Sina Weibo service, where she has 4.9 million followers.
Some in South Korea, whose government does not allow people to possess guns privately, also blamed a lack of gun control in the United States for the high number of deaths in Connecticut.
Chosun Ilbo, South Korea's top daily, speculated in an online report that it appears "inevitable" that the shooting will prompt the U.S. government to consider tighter gun control.
In Thailand, which has one of Asia's highest rates of murder by firearms and has seen schools attacked by Islamist insurgents in its southern provinces, a columnist for the English-language daily newspaper The Nation blamed American culture for fostering a climate of violence.
"Repeated incidents of gunmen killing innocent people have shocked the Americans or us, but also made most people ignore it quickly," Thanong Khanthong wrote on Twitter. "Intentionally or not, Hollywood and video games have prepared people's mind to see killings and violence as normal and acceptable," he wrote.
Condolences poured in also from Baghdad.
"We feel sorry for the victims and their families," said Hassan Sabah, 30, owner of stationary shop in eastern Baghdad. "This tragic incident shows there is no violence-free society in the world, even in Western and non-Muslim countries."
Samir Abdul-Karim, a 40-year-old government employee from eastern Baghdad said the attack "shows clearly that U.S. society is not perfect and the Americans do have people with criminal minds and who are ready to kill for the silliest reasons. "
He added, "If such an attack happened in Iraq or Afghanistan, I am sure the U.S. media would have seized the chance to depict the Arabs or Muslims as savage people who do not hesitate to kill children. "
Afghan President Hamid Karzai expressed his condolences to the American nation at the start of his remarks in Kabul on Saturday about Afghanistan's foreign policy.
"Such incidents should not happen anywhere in the world," Karzai said, adding that Afghanistan frequently witnesses such tragedies and can sympathize with those affected.
Japanese Prime Minister Yoshihiko Noda sent a condolence message to Obama for the families of the victims.
"The sympathy of the Japanese people is with the American people," he said. In Japan, guns are severely restricted and there are extremely few gun-related crimes.
In the Philippines, a society often afflicted by gun violence, President Benigno Aquino III said he and the Filipino people stand beside the United States "with bowed heads, yet in deep admiration over the manner in which the American people have reached out to comfort the afflicted, and to search for answers that will give meaning and hope to this grim event.
"We pray for healing, and that this heartbreak will never be visited on any community ever again," Aquino said in a statement tweeted by deputy presidential spokesman Abigail Valte.