At WVU, Frisbee and other researchers are poring over blood tests and other data assembled as part of a huge study of C8's possible impacts on the health of nearly 70,000 residents near the Washington Works plant.
The C8 Health Project is a multi-year effort to examine the chemical's possible effects on mid-Ohio Valley residents. It is funded by major portions of a $107.6 million settlement paid by DuPont to settle a lawsuit alleging the company poisoned residents' drinking water with C8. The settlement is also funding a related examination by a three-person science team of possible C8 links to adverse health effects.
In the new study, Frisbee and her colleagues studied blood samples from nearly 12,500 children and teens from the C8 Health Project data.
They found that higher PFOA levels were associated with increased total cholesterol and LDL or "bad" cholesterol. Higher levels of a related chemical, PFOS, were associated with increased total cholesterol, LDL cholesterol and HDL or "good" cholesterol.
On average, the one-fifth of children and teens with the highest PFOA levels had total cholesterol levels 4.6 milligrams per deciliter higher and LDL cholesterol levels 3.8 milligrams per deciliter higher than the one-fifth with the lowest PFOA levels.
"The non-linear nature of the observed associations, particularly for PFOA, suggests a possible saturation point in an underlying physiologic mechanism," the study authors wrote. "PFOA and PFOS specifically, and possibly perfluoroalkyl acids as a general class, appear to be associated with serum lipids, and the association seems to exist at levels of PFOA and PFOS exposure that are in the range characterized by nationally representative studies."
Learn about the C8 Health Project at http://www.hsc.wvu.edu/som/cmed/c8/Reach Ken Ward Jr. at kw...@wvgazette.com or 304-348-1702.