McNeil hit 3 of 6 3-pointers en route to 19 points and the Red Dragons hit 6 of 12 from beyond the arc as a team, but 25 turnovers and a drastic rebounding disadvantage proved too much to overcome in the end.
SC also took 64 shots compared to just 33 for the Red Dragons.
"I really feel like as the game went on, we were playing six or seven guys and it wore us down physically," St. Albans coach Marshall Kiser said. "We're not going to play catch-up against South Charleston. I was very proud of our effort and I thought our kids fought hard.
"South Charleston has so much talent and they're so athletic that teams like our team and a lot of teams in this conference have to play so close to perfect to be competitive at the end, and it's so hard to do that."
To his point, 11 different players scored for South Charleston compared to only six for St. Albans.
The deciding run came with the score tied at 35 midway through the third quarter as Cunningham scored eight points during a 26-6 stretch.
Taylor Clark added 15 points for the Red Dragons.
Cunningham, Kincaid and Moles had four steals apiece for South Charleston.
Reach Ryan Pritt at 304-348-7948, ryan.pr...@wvgazette.com, or follow him at twitter.com/RPritt.