Patrick was clearly disappointed with her finish, even though she ran inside the top-10 the entire race. When the race was on the line, though, she was schooled by Earnhardt, who made his move for the win.
Still, Patrick became the first woman in history to lead laps in the 500 when she passed Michael Waltrip on a restart on Lap 90. She stayed on the point for two laps, then was shuffled back to third. She ended up leading five laps, another groundbreaking moment for Patrick, who in 2005 as a rookie became the first woman to lead the Indianapolis 500.
Janet Guthrie was the first woman to lead laps at NASCAR's top Cup Series, in 1977 at Ontario, where she led five laps under caution.
"Dale did a nice job and showed what happens when you plan it out, you drop back and get that momentum. You are able to go to the front,'' Patrick said. "I think he taught me something. I'm sure I'll watch the race and there will be other scenarios I see that can teach me, too.''
Earnhardt was impressed, nonetheless.
"She's going to make a lot of history all year long. It's going to be a lot of fun to watch her progress,'' said Earnhardt Jr. "Every time I've seen her in a pretty hectic situation, she always really remained calm. She's got a great level head. She's a racer. She knows what's coming. She's smart about her decisions. She knew what to do today as far as track position and not taking risks. I enjoy racing with her.''
The field was weakened by an early nine-car accident that knocked out race favorite Kevin Harvick and sentimental favorite Tony Stewart.
Harvick had won two support races coming into the 500 to cement himself as the driver to beat, but the accident sent him home with a 42nd place finish.
Stewart, meanwhile, dropped to 0-for-15 in one of the few races the three-time NASCAR champion has never won.
"If I didn't tell you I was heartbroken and disappointed, I'd be lying to you,'' Stewart said.
That accident also took former winner Jamie McMurray, his Chip Ganassi Racing teammate Juan Pablo Montoya, and Kasey Kahne out of contention.
The next accident - involving nine cars - came 105 laps later and brought a thankful end to Speedweeks for Carl Edwards. He was caught in his fifth accident since testing last month, and this wreck collected six other Ford drivers.
The field suddenly had six Toyota drivers at the front as Joe Gibbs Racing and Michael Waltrip Racing drivers took control of the race. But JGR's day blew up - literally - when the team was running 1-2-3 with Matt Kenseth, Denny Hamlin and Kyle Busch setting the pace.
Kenseth, who led a race-high 86 laps, went to pit road first with a transmission issue, and Busch was right behind him with a blown engine. Busch was already in street clothes watching as Hamlin led the field.
"It's a little devastating when you are running 1-2-3 like that,'' Busch said.