The Tigers finished with four turnovers, three interceptions and a fumble.
The Tigers bounced back to take a 21-14 halftime lead on a Devin Wiley 15-yard run, a 38-yard touchdown pass from Spradin and a 4-yard run by Dustin Smith. Stowers added a 51-yard run for Sissonville.
After amassing 254 yards of total offense in the first half, the Tigers finished with 302 yards, just 48 total yards in the second half.
The Indians ran off 26 unanswered points in the second half on 22-yard pass reception by Miller, Stowers' 7-yard run, Crawford's 1-yard run, and Mowrer's 2-yard run, his second of the night.
"I just want to thank God for putting me in a situation to coach these young men," an overjoyed Smolder said. "I have a great group of kids. We are working hard and trying to do the right thing. It's just a blessing to be here in Sissonville."
The Tigers were led by Smith, who rushed for 80 yards and a touchdown, and Wiley rushed for 37 yards and had 43 yards receiving with a touchdown.
When asked about the eligibility of running back DeShawn Alexander, son of former WVU and NFL running back Robert Alexander, Barker said, "We get to find out Monday. Unfortunately, he will have to do his 14 practices, so he wouldn't be ready until midseason."
Alexander appeared in six games last year after transferring from St. Albans and had a 125-yard rushing performance in the playoffs.