Ali Burdette, Chelsey Parkins and Olivia Dunn had two hits apiece for the Bison (30-4). Rachel Roque and Shalyn Greer each had a home run for the White Falcons (20-12).
Buffalo hosts Doddridge County at 6 p.m. Thursday for the Region 4 title and a bid to the state tournament.
Tabitha Ferguson added a two-run homer for the Hillbillies (20-5). Jordan Lewis and Mackenzie Smith each had two-run homers for the Tide (24-8).
Man hosts the winner of Fayetteville-Montcalm for the region title at 6 p.m. Thursday.
Jacey Parsons drove in a run for the Pioneers (25-6). Hanna Wooten had an RBI for the Tigers (15-17). Wayne hosts Sissonville in the Region 4 title game Thursday.